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KMID : 1007520100190061573
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Food Science and Biotechnology
2010 Volume.19 No. 6 p.1573 ~ p.1578
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Inhibitory Effects of Water Extracts of Fermented Rice Bran on Allergic Response
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Fan Jiang-Ping
Choi Kyoung-Min
Han Gi-Dong
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Abstract
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In this study, the effects of water extracts of fermented rice bran (FRBE) on immediate-type allergic reactions in vitro (RBL-2H3 cell line) and in vivo [ovalbumin (OVA) sensitized mice model] were investigated. FRBE inhibited β-hexosaminidase release from RBL-2H3 cells activated by anti-dinitrophenyl (DNP) IgE while FRBE pretreatment profoundly inhibited the systemic allergic reaction induced by compound 48/80. Moreover, FRBE had a significant inhibitory effect on the mRNA expression of anti-DNP IgE-induced tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-4, IL-6, and IL- 10, all of which mediate inflammatory reactions triggered by allergic reaction. To determine the mRNA levels of cytokines in an OVA-sensitized mice model after FRBE treatment, spleen cells were harvested with several concentrations of FRBE. The FRBE-treated group showed decreased levels of TNF-α, IFN-γ, IL-6, and IL-10. These results suggest that FRBE suppressed allergic and inflammatory reactions through inhibition of degranulation, histamine release, and pro-inflammatory cytokine production from mast cells.
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KEYWORD
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water extract of fermented rice bran, allergic reaction, RBL-2H3 cell, β-hexosaminidase, pro-inflammatory chemotactic cytokine
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